Christopher Mirabelli

DR. Christopher MIRABELLI has served as Chairman of the Board of
Directors, President and Chief Executive Officer since July 1993. Dr.
Mirabelli was a founder of Isis Pharmaceuticals, Inc., a biotechnology
company, where he served as Executive Vice President from 1992 to 1993,
Senior Vice President of Research and Preclinical Development from 1991
to 1992, and Vice President of Research from 1989 to 1991. From 1981 to
1989, Dr. Mirabelli served in various positions at SmithKline & French
Laboratories, most recently as Director of Molecular Pharmacology. Dr.
Mirabelli received his B.S. in Biology from the State University of New
York at Fredonia and his Ph.D. in Pharmacology from Baylor College of
Medicine.